Helen Walden, School of Molecular Biosciences, CMVLS, University of Glasgow
Regulation of DNA Repair by Monoubiquitin Signals
More about Helen's group work: Link
Papers mentioned in the talk:
Lemonidis, K. , Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. and Walden, H.(2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.EMBO Journal, 42(3), e111898. (doi: 10.15252/embj.2022111898) (PMID:36385258)(PMCID:PMC9890228)
Rennie, M. L. , Arkinson, C., Chaugule, V. K. and Walden, H. (2022) Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Science Advances, 8(39), eabq6353. (doi: 10.1126/sciadv.abq6353) (PMID:36170365) (PMCID:PMC9519042)
Lemonidis, K. , Arkinson, C., Rennie, M. L. and Walden, H. (2022) Mechanism, specificity and function of FANCD2‐FANCI ubiquitination and deubiquitination. FEBS Journal, 289(16), pp. 4811-4829. (doi: 10.1111/febs.16077) (PMID:34137174)
Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Toth, R. and Walden, H. (2021) Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nature Structural and Molecular Biology, 28(4), pp. 356-364. (doi: 10.1038/s41594-021-00576-8) (PMID:33795880)
Rennie, M. L. , Lemonidis, K. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. , Spagnolo, L.and Walden, H. (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21(7), e50133. (doi: 10.15252/embr.202050133)(PMID:32510829) (PMCID:PMC7332966)
Arkinson, C., Chaugule, V. K., Toth, R. and Walden, H. (2018) Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1. Life Science Alliance, 1(5),e201800162. (doi: 10.26508/lsa.201800162) (PMID:30456385) (PMCID:PMC6238601)
Hodson, C., Purkiss, A., Miles, J. A. and Walden, H. (2014) Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection. Structure, 22(2), pp. 337-344.(doi: 10.1016/j.str.2013.12.004) (PMID:24389026) (PMCID:PMC3979106)