Briony Yorke: Seeing the light - the role of UV radiation in cataract formation

Briony Yorke, University of Leeds

Seeing the light - the role of UV radiation in cataract formation

School of Molecular Biosciences, University of Glasgow external Seminar hosted by Mads Gabrielson

Sketch about the scientific talk by Briony Yorke about the detailed biochemistry on how crystalin proteins in the lens of the eye respond to UV. Investigated using time resolved X-ray crystallography. More detail in the linked papers.


More about Briony Yorke's work: Link to University Profile

Papers mentioned in the talk:

Ochmann M, Harich J, Ma R, Freibert A, Kim Y, Gopannagari M, Hong DH, Nam D, Kim S, Kim M, Eom I, Lee JH, Yorke BA, Kim TK, Huse N. 2024. UV photochemistry of the L-cystine disulfide bridge in aqueous solution investigated by femtosecond X-ray absorption spectroscopy. Nature Communications. 15.

Hill JA, Nyathi Y, Horrell S, von Stetten D, Axford D, Owen RL, Beddard GS, Pearson AR, Ginn HM, Yorke BA. 2024. An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin. Communications Chemistry. 7

Hill J, Nyathi Y, Yorke B. 2022. A29: UV-related cataract formation: insights from serial synchrotron crystallography. Acta Crystallographica Section A Foundations and Advances. a29-a29 A78