Michelle Peckham, University of Leeds, UK

Muscles, myosin and mechanobiology

Papers mentioned in the talk:

Parker F, Tang AAS, Rogers B, Carrington G, dos Remedios C, Li A, Tomlinson D, Peckham M. 2023. Affimers targeting proteins in the cardiomyocyte Z-disc: Novel tools that improve imaging of heart tissue. Frontiers in Cardiovascular Medicine. 10

Wolny M, Batchelor M, Bartlett GJ, Baker EG, Kurzawa M, Knight PJ, Dougan L, Woolfson DN, Paci E, Peckham M. 2017. Characterization of long and stable de novo single alpha-helix domains provides novel insight into their stability. Scientific Reports. 7

Baboolal TG, Mashanov GI, Nenasheva TA, Peckham M, Molloy JE. 2016. A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip. The Journal of Biological Chemistry. 291(43), pp. 22373-22385

Knight P.J., Thirumurugan K., Xu Y., Wang F., Kalverda A.P., Stafford III W.F., Sellers J.R., Peckham M. The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head (2005) Journal of Biological Chemistry, 280 (41) , pp. 34702-34708

Peckham M., Knight P. J. (2009). When a predicted coiled coil is really a single α-helix, in myosins and other proteins. Soft Matter 5, 2493-2503.

More of the background ones (thank you Michelle!)

PMID: 34863916 : Luis and Schnorrer (mechanobiology of muscle and myofibrils)

PMID: 34745373: Ban der Pijl – for titin signalling/sarcomere mechanics

PMID: 11740494: Veigel et al., 2002 – ‘gated gait of myosin 5;

PMID: 20935627 Kodera et al., 2010 – AFM myosin 5

PMID: 25748137 Andrecka et al: iSCAT myosin 5

Gravett et al: bioRxiv 2023.03.19.533260 – for myosin lever structure and stiffness

PMID: 20018767: Baboolal et al., 2009: SAH in Myo5a

PMID: 25122759: Wolny et al., 2014: SAH is constant force spring.

Part of the

MR added: