James M Murphy: Licence to kill: understanding how the zombie protein, MLKL, is triggered to kill cells by necroptosis

School of Molecular Biosciences, University of Glasgow

 External Seminar hosted by

Helen Walden

Link to James' profile page at WEHI, Melbourne Australia

Some papers mentioned: 

Mace & Murphy There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling. JBC REVIEWS| VOLUME 296, 100705

Samson et al. MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis Nature Communications volume 11, Article number: 3151 (2020) 

Garnish et al. Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis. Nature Communications (2021) 12:2211