Sandrine Humbert: Huntington Disease as a neurodevelopmental disorder with adult-onset manifestations

Sandrine Humbert

gin (Grenoble Institut Neurosciences) 

Twitter: @HumbertSLab

This presentation was part of the: @WorldWideNeuro #WWNDev online talks via Zoom/YouTube: World-Wide.ORG

Some of the papers mentioned:

Tomasz J. Nowakowski, et al. Neuron 91, 6, 1219-1227.

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development.

Monia Barnat et al. Neuron. 2017;93(1):99-114.Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.

Aldrin E. Molero, et al. PNAS 2016, 113 (20) 5736-5741.

Developmental pathogenesis of Huntington’s disease

Frédéric Saudou & Sandrine Humbert. Neuron 89, 5, P910-926, 2016.
The Biology of Huntingtin 

Monia Barnat et al. SCIENCE, 2020, 369, 6505, 787-793.
Huntington’s disease alters human neurodevelopment. 

Mariacristina Capizzi,  et al. Neuron 2022
Developmental defects in Huntington’s disease show that axonal growth and microtubule reorganization require NUMA1. 

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