Karl Burgess: Metabolomic techniques and their application: from Robert Burns to metabolic flux in cells
Karl Burgess
University of Edinburgh, EdinOmics
Metabolomic techniques and their application: from Robert Burns to metabolic flux in cells
Karl provided a history of his engagement with and an introduction to metabolomics, as well as a history of the technical developments in his lab and Glasgow Polyomics. He used the identification of Robert Burns' documents as an illustration of the power of this technique to help verify originality damage free. He also showcased the highly successful collaboration between his group, Polyomics and the Dalby group. Ending on a timeseries analysis of extra- and intracellular metabolite changes over time accessed at 4min intervals.
So early at Edinburgh that he has yet to set up a webpage for the group...
Paper Portal:
Papers mentioned/referred to in the talk:
Newton, J, Ramage, G., Gadegaard, N. Zachs, W. Rogers, S, Barrett, MP, Carruthers, G & Karl Burgess Minimally-destructive atmospheric ionisation mass spectrometry authenticates authorship of historical manuscripts Scientific Reports volume 8, Article number: 10944 (2018)Oliver S.G. et al. (1998) Systematic functional analysis of the yeast genome. Trends Biotechnol ., 16, 373–378.
Gloaguen, Y Morton F, Daly R, Gurden R, Rogers S, Wandy J, Wilson D, Barrett MP, Karl Burgess PiMP my metabolome: an integrated, web-based tool for LC-MS metabolomics data Bioinformatics, Volume 33, Issue 24, 15 December 2017, Pages 4007–4009
e.g. collaborative work with Matt Dalby:
Tsimbouri PM1, McMurray RJ, Burgess KV, Alakpa EV, Reynolds PM, Murawski K, Kingham E, Oreffo RO, Gadegaard N, Dalby MJ. Using nanotopography and metabolomics to identify biochemical effectors of multipotency. ACS Nano. 2012 6(11):10239-49.
Software tools mentioned and accessible:
MetExploreViz: https://metexplore.toulouse.inra.fr/metexploreViz/doc/index.phpPiMP: http://polyomics.mvls.gla.ac.uk (uh it seems that it is currently not accepting new ppl to register...)
