Kristian Franze: The mechanical regulation of neuronal development and regeneration

Kristian Franze

10.9.2019 

University of Cambridge, Dept. Physiology, Development & Neuroscience

 
(Missing page 3 when material has been published...)

 Q1: How do microtubules organise inside axons 'all out' & why? (Left)
A: invent new AI supported analysis of Kymographs (https://elifesciences.org/articles/42288)
C: dynactin

Q2: How does a neuron know when to stop growing? (Right)

 Live #sketchnotes
More about Kristian’s work: https://www.pdn.cam.ac.uk/directory/kristian-franze

Some recent publications mentioned in or relevant to the talk: 

Segel M, Neumann B, Hill MFE, Weber IP, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez G, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM, Chalut KF: Niche stiffness underlies the ageing of central nervous system progenitor cells. Nature doi: 10.1038/s41586-019-1484-9 (2019)

Barriga EH, Franze K, Charras G, Mayor R: Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo. Nature 554:523–527 (2018)

Koser DE, Thompson AJ, Foster SK, Dwivedy A, Pillai EK, Sheridan GK, Svoboda H, Viana M, Costa LdF, Guck J, Holt CE, Franze K: Mechanosensing is critical for axon growth in the developing brain. Nature Neuroscience 19(12):1592-1598 (2016)
Moeendarbary E, Weber IP, Sheridan GK, Koser DE, Solemane S, Haenzie B, Bradbury EJ, Fawcett J, Franze K: The soft mechanical signature of glial scars in the central nervous system. Nature Communications 8:14787 (2017)

Chew, D.J., Fawcett, J.W., and Andrews, M.R. (2012). The challenges of long-distance axon regeneration in the injured CNS. Prog Brain Res 201, 253-294.
Musick, K.M., Rigosa, J., Narasimhan, S., Wurth, S., Capogrosso, M., Chew, D.J., Fawcett, J.W., Micera, S., and Lacour, S.P. (2015). Chronic multichannel neural recordings from soft regenerative microchannel electrodes during gait. Sci Rep 5, 14363.