Stephen Tate: Minority MOMP or the Dark Side of Apoptosis

25.11.2016

Prof Stephen Tate

The Beatson Institute for Cancer Research, CRUK, University of Glasgow


Papers mentioned in the talk:
Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SW. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol Cell 57: 860-72, 2015

Lopez J, Tait SW. Mitochondrial apoptosis: killing cancer using the enemy within. Br J Cancer 112: 957-62, 2015
Ichim G, Tait SWG. A fate worse than death: apoptosis as an oncogenic process. Nat Rev Cancer 16: 539-48, 2016


Pecot J, Maillet L, Le Pen J, Vuillier C, Trecesson SC, Fetiveau A, Sarosiek KA, Bock FJ, Braun F, Letai A, Tait SW, Gautier F, Juin PP. Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance. Cell Rep 17: 3347-3358, 2016

Giampazolias E, Tait SWG. Mitochondria and the hallmarks of cancer. FEBS J 283: 803-14, 2016
Lopez J, Bessou M, Riley JS, Giampazolias E, Todt F, Rochegue T, Oberst A, Green DR, Edlich F, Ichim G, Tait SWG. Mito-priming as a method to engineer Bcl-2 addiction. Nat Commun 2016; 7: 10538

More about Stephen: http://www.beatson.gla.ac.uk/Cancer-Metabolism-Growth-and-Survival/stephen-tait-mitochondria-and-cell-death.html