Paula Sweeten: Use of synthetic ethyl acrylate polymers in the development of an HSC maintenance system

PhD progress talk

19.4.2016

with Matthew Dalby, Manuel Salmeron-Sanchez & Joanne Mountford

More about Paula: http://www.cceuog.co.uk


Acronyms used:

• GF: growth factors
• MSC: mesenchymal stem cells 
• HSC: haematopoetic stem cells
• 
  

Growth factors:

• BMP: Bone morphogenetic protein
• NGF: Nerve growth factor
• VEGF: Vascular endothelial growth factor
• PDGF: Platelet derived growth factor

Materials:

• PEA: poly ethyl acrylate (e.g. Bathawab et al. 2015 Langmuir)
• PAH: 

Cytokines:

• IL7: Interleukin 7
• SCF: Stem cell factor
• CXCL12: Stromal cell derived factor 12 
• OPN: Osteopontin
• Ang1: Angiopoetin
• tpo: thrombopoietin
• VCAM1: Vascular cell adhesion protein 1 

Outcome measures:

• SCF: Stem cell factor
• VCAM1: Vascular cell adhesion protein 1
• OPN: Osteopontin

Paper mentioned: not Rodrigues but:  Fan et al. 2007 Tethered Epidermal Growth Factor Provides a Survival Advantage to Mesenchymal Stem Cells. Stem Cells 25 (5)1241–1251