1st of April 2015, Chichley Hall
In his talk Henrik showed how gene regulatory networks interact to enable mechanical control of stem cells. This was enabled by a unique combination of analytical modelling, with sophisticated image analysis of the movement and positioning of cells which express spatio-temporal regulated proteins (e.g. Pin1, WUS, ...). Applied to subcellular aspects of plant cell structure the orientation of the cytoskeleton directed by proxy the structural orientation of cellulose in the cell wall., and the direction of microtubules in the epidermis could be explained by the stress pattern within the cells. This was possible due to the close collaboration with EM the models developed get tested, modified and in return analysis directed by the predictive power of the models.
More on Henriks work: http://www.slcu.cam.ac.uk/directory/jonsson-henrik
This talk was part of a workshop on "Cell Mechanobiology" organised by Rene de Borst, which took place April 1st and 2nd 2015, with support by the Royal Society at Chicheley Hall. for the programme details see: http://bio-mat-sketches-mor.blogspot.co.uk/2015/04/cell-mechanobiology-workshop-1st-2nd.html
