I have been attending this since its first instalment, and it has never disappointed - Prof. Rychly (University of Rostock, Germany) always brings together an excellent set of speakers that enthuse the audience of about 140. Very interactive single session style meeting with an intense poster and a good exhibition. This together with the seaside in Warnemünde makes for an unforgettable meeting, every time.
INTERFACE BIOLOGY of IMPLANTS
Wednesday 6th of May19:00–20:00
Welcome Session Joachim Rychly (Rostock/DE, THE Organizer)
Welcome Address:
Wolfgang Schareck (Rostock/DE, Rector of the University of Rostock)
Keynote Lecture: Dynamic Cross-Talk Between Cell-Matrix Adhesion and the Cytoskeleton
Alexander Bershadsky (Rehovot, Israel/IL; Singapore/SG)
Thursday 7th of May
09:00–12:35 Session 1 – Generation of Regenerative Materials
Co-Chairs: N. Ma (Helmholtz Center, Teltow/DE) &
K. Leong (Columbia University New York, NY/US)
09:00 Designing Nature and Host Inspired Biomaterials Systems
A. Pandit (Galway/IE)
09:30 Engineered Fibrous Hydrogels for Applications in Regenerative Medicine
J. Burdick (Philadelphia, PA/US)
10:00 Biofunctional Hydrogels for Cell Delivery and Tissue Repair
A. Garcia (Atlanta, GA/US)
10:30 Reversible Photoswitching of Integrin-mediated Cell Adhesion
C. Selhuber-Unkel (Kiel/DE)
11:05 Microfabricated Hydrogel Culture Platform to Study Cell Response to Drugs
M. Textor (Zurich/CH)
11:35 High Throughput Materials Discovery with Polymer Microarrays
M. R. Alexander (Nottingham/GB)
12:05 Polyelectrolyte Multilayers with Controlled Stiffness Influence the Response of Human Adipose-Derived Stem Cells
M. Niepel (Halle a. d. S./DE)
12:20 Covalent Coating of Human Extracellular Matrix on Titanium Implant Surfaces
Using Click Chemistry
M. Ruff (Stuttgart/DE) cancelled due to train drivers strike
INTERFACE BIOLOGY of IMPLANTS
Wednesday 6th of May19:00–20:00
Welcome Session Joachim Rychly (Rostock/DE, THE Organizer)
Welcome Address:
Wolfgang Schareck (Rostock/DE, Rector of the University of Rostock)
Keynote Lecture: Dynamic Cross-Talk Between Cell-Matrix Adhesion and the Cytoskeleton
Alexander Bershadsky (Rehovot, Israel/IL; Singapore/SG)
Thursday 7th of May
09:00–12:35 Session 1 – Generation of Regenerative Materials
Co-Chairs: N. Ma (Helmholtz Center, Teltow/DE) &
K. Leong (Columbia University New York, NY/US)
09:00 Designing Nature and Host Inspired Biomaterials Systems
A. Pandit (Galway/IE)
09:30 Engineered Fibrous Hydrogels for Applications in Regenerative Medicine
J. Burdick (Philadelphia, PA/US)
10:00 Biofunctional Hydrogels for Cell Delivery and Tissue Repair
A. Garcia (Atlanta, GA/US)
10:30 Reversible Photoswitching of Integrin-mediated Cell Adhesion
C. Selhuber-Unkel (Kiel/DE)
11:05 Microfabricated Hydrogel Culture Platform to Study Cell Response to Drugs
M. Textor (Zurich/CH)
11:35 High Throughput Materials Discovery with Polymer Microarrays
M. R. Alexander (Nottingham/GB)
12:05 Polyelectrolyte Multilayers with Controlled Stiffness Influence the Response of Human Adipose-Derived Stem Cells
M. Niepel (Halle a. d. S./DE)
12:20 Covalent Coating of Human Extracellular Matrix on Titanium Implant Surfaces
Using Click Chemistry
M. Ruff (Stuttgart/DE) cancelled due to train drivers strike
13:15 QITM – New generation of quantitative nanomechanical atomic force microscopy measurements in life sciences
C. Pettersson (JPK Instruments AG) [apologies, not covered]
13:35 Poster Session I
15:00–18:20 Session 2 – Cellular Mechanisms
Co-Chairs B. Nebe (Rostock University Medical Center, Rostock/DE) & M. Riehle (University of Glasgow, Glasgow/GB)
15:00 Bioengineering of Direct Cellular Reprogramming
K. W. Leong (New York, NY/US) cancelled
15:00 Fibroblasts and Biomaterials: A Recipe for Fibrosis and Scar
T. H. Barker (Atlanta, GA/US)
16:00 Determination of Macrophage Polarization in Biomimetic 3D Microenvironments
T. Pompe (Leipzig/DE) cancelled due to train drivers strike
15:30 Combinatorial Biomolecular Nano-patterning for High-throughput Screening of Stem Cell Behavior
R. Ogaki (Aarhus/DK)
C. Pettersson (JPK Instruments AG) [apologies, not covered]
13:35 Poster Session I
15:00–18:20 Session 2 – Cellular Mechanisms
Co-Chairs B. Nebe (Rostock University Medical Center, Rostock/DE) & M. Riehle (University of Glasgow, Glasgow/GB)
15:00 Bioengineering of Direct Cellular Reprogramming
K. W. Leong (New York, NY/US) cancelled
15:00 Fibroblasts and Biomaterials: A Recipe for Fibrosis and Scar
T. H. Barker (Atlanta, GA/US)
16:00 Determination of Macrophage Polarization in Biomimetic 3D Microenvironments
T. Pompe (Leipzig/DE) cancelled due to train drivers strike
15:30 Combinatorial Biomolecular Nano-patterning for High-throughput Screening of Stem Cell Behavior
R. Ogaki (Aarhus/DK)
15:50 Interaction of sulfated hyaluronan with TGF-ß alters receptor complex formation and impairs growth factor signaling
Linda Hübner
16:30 Coffee Break & Industrial Exhibition
16:50 Modulation of Integrin-dependent Cell-matrix Adhesions and Signaling by Adapter Protein Recruitment and Posttranslational Modification
B. Wehrle-Haller (Geneva/CH)
17:20 Dynamic Hydrogel Niches Through Photochemical Reactions
K. Kyburz (Boulder, CO/US) cancelled
17:50 Impact of Cell Culture Matrix Stiffness and Stretch on Expression and Localisation of Mechanotransducers YAP and TAZ in Aortic Valvular Interstitial Cells
C. Dittfeld (Dresden/DE)
Friday, 8 May 2015
09:00–12:20 Session 3 – Material Induced Biological Reponses
Co-Chairs K. Peters (Rostock University Medical Center, Rostock/DE) & C. J. Kirkpatrick (University of Mainz, Mainz/DE)
09:00 Attachment Onto Nanostructured Black Silicon Antibacterial Surfaces: the Clash Between Eukaryotic Cells versus Pathogenic Bacteria
E. Ivanova (Hawthorn/AU)
09:30 Engineering Tissues via Matrix-Guided Stem Cell Self-organization
M. P. Lutolf (Lausanne/CH)
10:00 Non-pathogenic Bacteria as Functional Biointerfaces Between Synthetic Materials and Mammalian Cells
M. Salmeron-Sanchez (Glasgow/GB)
10:15 Opposing Growth Factor Gradients to Create Distinct Tissue Patterning: In-vivo Feasibility Study at the Bone-cartilage Junction
E. Lippens (Berlin/GE)
10:30 Analysis of Osteoclastogenesis/Osteoblastogenesis Using Human Bone Marrow Derived Co-cultures on Nanotopographical Titania Surfaces
Linda Hübner
16:30 Coffee Break & Industrial Exhibition
16:50 Modulation of Integrin-dependent Cell-matrix Adhesions and Signaling by Adapter Protein Recruitment and Posttranslational Modification
B. Wehrle-Haller (Geneva/CH)
17:20 Dynamic Hydrogel Niches Through Photochemical Reactions
K. Kyburz (Boulder, CO/US) cancelled
17:50 Impact of Cell Culture Matrix Stiffness and Stretch on Expression and Localisation of Mechanotransducers YAP and TAZ in Aortic Valvular Interstitial Cells
C. Dittfeld (Dresden/DE)
Friday, 8 May 2015
09:00–12:20 Session 3 – Material Induced Biological Reponses
Co-Chairs K. Peters (Rostock University Medical Center, Rostock/DE) & C. J. Kirkpatrick (University of Mainz, Mainz/DE)
09:00 Attachment Onto Nanostructured Black Silicon Antibacterial Surfaces: the Clash Between Eukaryotic Cells versus Pathogenic Bacteria
E. Ivanova (Hawthorn/AU)
09:30 Engineering Tissues via Matrix-Guided Stem Cell Self-organization
M. P. Lutolf (Lausanne/CH)
10:00 Non-pathogenic Bacteria as Functional Biointerfaces Between Synthetic Materials and Mammalian Cells
M. Salmeron-Sanchez (Glasgow/GB)
10:15 Opposing Growth Factor Gradients to Create Distinct Tissue Patterning: In-vivo Feasibility Study at the Bone-cartilage Junction
E. Lippens (Berlin/GE)
10:30 Analysis of Osteoclastogenesis/Osteoblastogenesis Using Human Bone Marrow Derived Co-cultures on Nanotopographical Titania Surfaces
P. M. Tsimbouri (Glasgow/GB)
10:45 Coffee Break & Industrial Exhibition
11:05 Characterizing the Bone-implant Interface Using Ex-vivo and In-vivo Approaches
P. Fratzl (Potsdam/DE)
11:35 Novel Mechanism Identified in Early Implant Healing in Rabbit Bone by Direct Viewing of the Interface
A. Boyde (London/GB)
11:50 Cellular Barrier Systems in Nanomedicine Research
10:45 Coffee Break & Industrial Exhibition
11:05 Characterizing the Bone-implant Interface Using Ex-vivo and In-vivo Approaches
P. Fratzl (Potsdam/DE)
11:35 Novel Mechanism Identified in Early Implant Healing in Rabbit Bone by Direct Viewing of the Interface
A. Boyde (London/GB)
11:50 Cellular Barrier Systems in Nanomedicine Research
C. J. Kirkpatrick (Mainz/DE)
12:20 Lunch Break
J. Lindenau (Carl Zeiss Microscopy)
13:20 Poster Session II
[sorry no more from here on as I left to head back to Glasgow...]
12:50 ATUMTome and ATLAS Array Tomography - automated large volume SEM imaging J. Lindenau (Carl Zeiss Microscopy)
13:20 Poster Session II
14:45–18:00 Session 4 – Mechanical Control of Cells Co-Chairs A. Bershadsky (Weizmann Institute, Rehovot/IL and Mechanobiology Institute, Singapore/SG) & J. de Boer (Maastricht/NL)
14:45 Second-generation Biosensors to Measure Molecular Cell Adhesion Forces in Cells
C. Grashoff (Planegg/DE)
14:45 Second-generation Biosensors to Measure Molecular Cell Adhesion Forces in Cells
C. Grashoff (Planegg/DE)
15:15 Mechanical Aspects of the Forceful Play of Macrophages with their Prey
V. Vogel (Zurich/CH)
16:15 Stress-stiffening Mediated Commitment Switch in Soft Responsive Hydrogels
R. Das (Nijmegen/NL)
16:50 Mechanobiology of Cell Reprogramming
S. Li (Berkeley, CA/US)
17:20 Understanding the Cell-extracellular Matrix Mechanical Link – from Molecular Roles to Emerging Behaviors
P. Roca-Cusachs (Barcelona/ES)
Short meeting summary (we left Friday 2pm):
We Ricky, Monica and myself really enjoyed our time at the meeting, all talks relevant to our work, an enthusiastic and welcoming audience that interacted with the speakers - good questions, and interesting discussions during the lunch/coffee breaks. Poster session very well visited and the presenters sometimes faced challenging but always friendly and interactive discussions. Interestingly two talks offered new hypothesis Alexander Bershadsky explained his and Tom Shemesh's model on how the molecular structure of mDia and F-actin could lead to the dynamic instabilities that were observed when the cells cytoskeleton organises itself whilst they sit on a perfectly round patch. The other hypothesis was put forward by Peter Frazl who offered an explanation on how tension could be built up in collagen by the secretion of hygroscopic molecules such as aggrcan; their local presence in the extracellular reduces the water tension in the collagen molecule, 'drying it out' a little bit. This reduction in water content of the collagen molecule leads to a change in tension, which can be observed in XRD. Other parts of note were the last talk by Marcus Textor, and a brief review of the scientific life of Joachim Rychly by James Kirkpatrick.
Good exhibition - for me interesting were the new "stick on microfluidics" kits from Ibidi, and a new machine to test nanomechanics of cells and materials (need to get the name...).
Evening out at the conference dinner on a boat up and down the Warne and cruising Rostock harbour, fish, fish, and more local specialties as well as wine and local beer. Very interactive and interesting discussions about all science, and well beyond.
16:15 Stress-stiffening Mediated Commitment Switch in Soft Responsive Hydrogels
R. Das (Nijmegen/NL)
16:50 Mechanobiology of Cell Reprogramming
S. Li (Berkeley, CA/US)
17:20 Understanding the Cell-extracellular Matrix Mechanical Link – from Molecular Roles to Emerging Behaviors
P. Roca-Cusachs (Barcelona/ES)
Short meeting summary (we left Friday 2pm):
We Ricky, Monica and myself really enjoyed our time at the meeting, all talks relevant to our work, an enthusiastic and welcoming audience that interacted with the speakers - good questions, and interesting discussions during the lunch/coffee breaks. Poster session very well visited and the presenters sometimes faced challenging but always friendly and interactive discussions. Interestingly two talks offered new hypothesis Alexander Bershadsky explained his and Tom Shemesh's model on how the molecular structure of mDia and F-actin could lead to the dynamic instabilities that were observed when the cells cytoskeleton organises itself whilst they sit on a perfectly round patch. The other hypothesis was put forward by Peter Frazl who offered an explanation on how tension could be built up in collagen by the secretion of hygroscopic molecules such as aggrcan; their local presence in the extracellular reduces the water tension in the collagen molecule, 'drying it out' a little bit. This reduction in water content of the collagen molecule leads to a change in tension, which can be observed in XRD. Other parts of note were the last talk by Marcus Textor, and a brief review of the scientific life of Joachim Rychly by James Kirkpatrick.
Good exhibition - for me interesting were the new "stick on microfluidics" kits from Ibidi, and a new machine to test nanomechanics of cells and materials (need to get the name...).
Evening out at the conference dinner on a boat up and down the Warne and cruising Rostock harbour, fish, fish, and more local specialties as well as wine and local beer. Very interactive and interesting discussions about all science, and well beyond.
A ferry leaving Rostock harbour...
Morning walk along the beach...