Adrien Hallou: Spatial mechano-transcriptomics: mapping mechanical forces and gene expression in tissues at single-cell resolution

Adrien Hallou

University of Oxford

Spatial mechano-transcriptomics: mapping mechanical forces and gene expression in tissues at single-cell resolution

Link to Lab Webpage

Papers relevant to the talk:

Connections between physics and metabolism in brain functions.

Mochel F, de Oyarzábal Sanz A, Pías Peleteiro L, Ribeiro-Constante J, Bassereau P, Chalut K, Cognet L, Cronin L, Hameroff S, López-Murcia FJ, Pillai EK, Sales-Pardo M, Straube A, Hallou A, Garcia-Cazorla A.iScience. 2026 Jan 7;29(2):114643. doi: 10.1016/j.isci.2026.114643. eCollection 2026 Feb 20 PMID: 41641103 

A computational pipeline for spatial mechano-transcriptomics.

Hallou A, He R, Simons BD, Dumitrascu B.Nat Methods. 2025 Apr;22(4):737-750. doi: 10.1038/s41592-025-02618-1. Epub 2025 Mar 17. PMID: 40097810

On growth and force: mechanical forces in development.

Hallou A, Brunet T.Development. 2020 Feb 17;147(4):dev187302. doi: 10.1242/dev.187302. PMID: 32066591

A magnetically actuated, optically sensed tensile testing method for mechanical characterization of soft biological tissues.

Rosalia L, Hallou A, Cochrane L, Savin T.Sci Adv. 2023 Jan 13;9(2):eade2522. doi: 10.1126/sciadv.ade2522. Epub 2023 Jan 11. PMID: 36630495

 

Deep learning for bioimage analysis in developmental biology.

Hallou A, Yevick HG, Dumitrascu B, Uhlmann V.Development. 2021 Sep 15;148(18):dev199616. doi: 10.1242/dev.199616. Epub 2021 Sep 7. PMID: 34490888