Andra C. Dumitru
UC Louvain, Be
Metabolic stress tunes nuclear viscoelasticiy
Papers that support the talk:
Pathological stiffening by crosslinking glycation of titin
View ORCID ProfileAgata Bak, View ORCID ProfileAndra C. Dumitru, Alejandro Clemente-Manteca, Enrique Calvo, View ORCID ProfileRoberto Silva-Rojas, Natalia Vicente, , Inés Martínez-Martín, Diana Velázquez-Carreras, Maria Rosaria Pricolo, Francisco M. Espinosa, João Almeida-Coelho, Carlos Pérez-Medina, Ricardo Garcia, Jesús Vázquez, Inês Falcão-Pires, Elías Herrero-Galán, View ORCID ProfileMiquel Adrover, View ORCID ProfileJorge Alegre-Cebollada BiorXiv: doi: https://doi.org/10.64898/2026.02.13.705744
Titin cleavage in living cardiomyocytes induces sarcomere disassembly but does not trigger cell proliferation.
Pricolo MR, López-Unzu MA, Vicente N, Morales-López C, Huerta-López C, Pérez-Franco W, Dumitru AC, Peña-Peña J, Espinosa FM, Sanchez MI, Garcia R, Silva-Rojas R, Torres M, Herrero-Galán E, Alegre-Cebollada J.J Biol Chem. 2026 Jul;302(7):113167. doi: 10.1016/j.jbc.2026.113167. Epub 2026 May 15. PMID: 42142587
Mechanically knocking out titin reveals protein tension loss as a trigger of muscle disease.
Silva-Rojas R, Vicente N, Gavilán-Herrera M, Labrador-Cantarero V, Sicilia J, Giménez-Sáez O, Dumitru AC, Sánchez MI, Gato-Vilaseca M, Velázquez-Carreras D, López JA, Vázquez J, Herrero-Galán E, López-Unzu MA, Pricolo MR, Alegre-Cebollada J.Nat Biomed Eng. 2025 Oct;9(10):1758-1774. doi: 10.1038/s41551-025-01403-x. Epub 2025 Jun 5. PMID: 40473933
Dumitru AC, Koehler M.J Struct Biol. 2023 Jun;215(2):107963. doi: 10.1016/j.jsb.2023.107963. Epub 2023 Apr 10. PMID: 37044358
