Alba Diz-Muñoz: More than the sum: how composite interfaces govern function


Alba Diz-Muñoz

EMBL, Heidelberg, De

More than the sum: how composite interfaces govern function



Papers that relate to the talk:
 
Deciphering mechanical determinants of morphological evolution.
Bailleul R, Cuny N, Khoromskaia D, Basu S, Bergamini G, Cucurachi P, Gabler F, Rupp S, Guse A, Curantz C, Swinhoe N, Cleves PA, Craggs J, Fujita S, Nakajima YI, Steenbergen PJ, Diz-Muñoz A, Salbreux G, Ikmi A.Cell. 2026 Apr 30;189(9):2598-2611.e18. doi: 10.1016/j.cell.2026.02.010. Epub 2026 Mar 20. PMID: 41864204 

Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics.
Verdys P, Rey Barroso J, Girel A, Vermeil J, Bergert M, Sanchez T, Métais A, Mangeat T, Bellard E, Bigot C, Astarie-Dequeker C, Labrousse A, Girard JP, Maridonneau-Parini I, Vérollet C, Lagarrigue F, Diz-Muñoz A, Heuvingh J, Piel M, du Roure O, Le Cabec V, Carréno S, Poincloux R.EMBO J. 2024 Nov;43(21):4822-4845. doi: 10.1038/s44318-024-00173-7. Epub 2024 Jul 18. PMID: 39026000 

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells.
Conti S, Venturini V, Cañellas-Socias A, Cortina C, Abenza JF, Stephan-Otto Attolini C, Middendorp Guerra E, Xu CK, Li JH, Rossetti L, Stassi G, Roca-Cusachs P, Diz-Muñoz A, Ruprecht V, Guck J, Batlle E, Labernadie A, Trepat X.Nat Commun. 2024 Apr 18;15(1):3363. doi: 10.1038/s41467-024-47227-2. PMID: 38637494 

Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles.
Sitarska E, Almeida SD, Beckwith MS, Stopp J, Czuchnowski J, Siggel M, Roessner R, Tschanz A, Ejsing C, Schwab Y, Kosinski J, Sixt M, Kreshuk A, Erzberger A, Diz-Muñoz A.Nat Commun. 2023 Sep 13;14(1):5644. doi: 10.1038/s41467-023-41173-1. PMID: 37704612 

Understanding the interplay of membrane trafficking, cell surface mechanics, and stem cell differentiation. Li JH, Trivedi V, Diz-Muñoz A. Semin Cell Dev Biol. 2023 Jan 15;133:123-134. doi: 10.1016/j.semcdb.2022.05.010. Epub 2022 May 28.PMID: 35641408

Dar S, Tesoro Moreno R, Palaia I, Gopalan AB, Sun ZG, Strauss L, Sprenger RR, Belmonte JM, Foster SK, Murrell M, Ejsing CS, Šarić A, Leptin M, and Diz-Muñoz A*. (2024). bioRxiv. doi: 10.1101/2024.10.14.618153.

The membrane-to-cortex distance regulates mDia1 activity to control cortical mechanics. 
Strauss L**, Lembo S**, Gérard SF, Siggel M, Cheng D, Bergert M, Foster SK, Vermeil J, Toro-Nahuelpan M, Fischer LM, Yu Q, Sitarska E, Chan CJ, Kosinski J, Piel M, du Roure O, Heuvingh J, Mahamid J, Diz-Muñoz A*. (2023). bioRxiv. doi: 10.1101/2023.01.31.526409. Nat Commun. In press.

Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A*. (2021). Cell Stem Cell. Feb 4;28(2):209-216.e4. PMID: 33207217.