Paul Shiels: The Exposome of Ageing and Ill Health

School of Molecular Biosciences Internal Seminar series 2023/24     17.1.24

Paul Shiels: The Exposome of Ageing and Ill Health 

School of Molecular Biosciences, CMVLS, University of Glasgow:

Organised by Brian Hudson

sketchnote drawing of the details that Paul mentioned in his talk - most are accessible through the papers that are linked below, This covers 50 minutes of a dense slightly meandering talk so sorry no detailed description easily possible

More about Paul's research: Linked here

Some of the papers mentioned in the talk (have a look at the research page above for free open access versions of some of these):

Kalogeropoulu, S. K., Rauch-Schmücking, H., Lloyd, E. J., Stenvinkel, P., Shiels, P. G. , Johnson, R. J., Fröbert, O., Redtenbacher, I., Burgener, I. A. and Painer-Gigler, J. (2023) Formerly bile-farmed bears as a model of accelerated ageing. Scientific Reports, 13, 9691.

Baptista, B. G., Fanton, S., Ribeiro, M., Cardozo, L. F.M.F., Regis, B., Alvarenga, L., Ribeiro-Alves, M., Berretta, A. A., Shiels, P. G. and Mafra, D. (2023) The effect of Brazilian green propolis extract on inflammation in patients with chronic kidney disease on peritoneal dialysis: a randomised double-blind controlled clinical trial. Phytomedicine, 114, 154731. 

Hill, C. et al. (2023) Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes. Genes, 14(5), 1029. 

Hobson, S., Arefin, S., Witasp, A., Hernandez, L., Kublickiene, K., Shiels, P.G. and Stenvinkel, P. (2023) Accelerated vascular aging in chronic kidney disease: the potential for novel therapies. Circulation Research, 132(8), pp. 950-969. 

Mafra, D., Ugochukwu, S. A., Borges, N. A., Cardozo, L. F. M. F., Stenvinkel, P. and Shiels, P. G. (2022) Food for healthier aging: power on your plate. Critical Reviews in Food Science and Nutrition.

Ebert, T., Tran, N. , Schurgers, L., Stenvinkel, P. and Shiels, P. G. (2022) Ageing – oxidative stress, PTMs and disease. Molecular Aspects of Medicine, 86, 101099. 

Witasp, A., Luttropp, K., Qureshi, A. R., Barany, P., Heimbürger, O., Wennberg, L., Ekström, T. J., Shiels, P. G. , Stenvinkel, P. and Nordfors, L. (2022) Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy. Scientific Reports, 12, 470. (doi: 10.1038/s41598-021-04321-5) 

Kemp, J. A., Paiva, B. R., dos Santos, H. F., Jesus, H. E., Craven, H., Ijaz, U. Z. , Borges, N. A., Shiels, P. G. and Mafra, D. (2021) The impact of enriched resistant starch type‐2 cookies on the gut microbiome in hemodialysis patients: a randomized controlled trial. Molecular Nutrition and Food Research, 65(19), 2100374. 

Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G. , Evenepoel, P. and Stenvinkel, P. (2021) Food as medicine: targeting the uraemic phenotype in chronic kidney disease. Nature Reviews Nephrology, 17, pp. 153-171. (PMID:32963366)