Laura Machesky: Signalling to the actin cytoskeleton driving tumour invasion and metastasis in pancreatic cancer
Laura Machesky
Signalling to the actin cytoskeleton driving tumour invasion and metastasis in pancreatic cancer
More about Laura's work: here with summary - here for linked papers
Papers mentioned in the talk:
Perera & Bardeesy Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up Cancer Discov; 5(12); 1247–6
DeBerardinis & Chandel Fundamentals of cancer metabolism Science Advances 2016:
Vol. 2, no. 5, e1600200
Kelly et al. Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs Developmental Cell 48(3) 2019, 313-328.e8
Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544.
Yu, X. and Machesky, L.M. (2012) Cells assemble invadopodia-like structures and invade into matrigel in a matrix metalloprotease dependent manner in the circular invasion assay. PLoS ONE, 7(2), e30605.
Another relevant Sketchnote: https://bio-mat-sketches-mor.blogspot.com/2016/06/vasilios-papalazarou-impact-of.html