Jan Riemer: Thiol oxidation in respiratory chain assembly and mitochondrial calcium signalling

Invited seminar at the Institute for
Molecular Cell and Systems Biology 

#MCSBSem


10.05.2016  


Prof. Jan Riemer
University of Cologne






Some of the papers mentioned in the talk: 



Fischer M, Horn S, Belkacemi A, Kojer K, Petrungaro C, Habich M, Ali M, Küttner V, Bien M, Kauff F, Dengjel J, Herrmann JM, Riemer J. (2013) Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells.Mol Biol Cell. 2013 Jul;24(14):2160-2170. doi: 10.1091/mbc.E12-12-0862


Herrmann J, Riemer J (2012). The mitochondrial disulfide relay: redox-regulated protein import into the intermembrane spaceJ Biol Chem. 2012 Feb 10;287(7):4426-33

Kojer K, Peleh V, Calabrese G, Herrmann JM, Riemer J. (2014) Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial IMS. Mol Biol Cell. 2015 Jan 15;26(2):195-204. doi: 10.1091/mbc.E14-10-1422

Kojer K, Bien M, Gangel H, Morgan B, Dick T.P, Riemer J. (2012). Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox stateEMBO J. 2012 Jun 15;31(14):3169-82

Morgan B, Ezeriņa D, Amoako TN, Riemer J, Seedorf M, Dick TP. (2013) Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nat Chem Biol. 2013 Feb;9(2):119-25. doi: 10.1038/nchembio.1142. doi: 10.1038/nchembio.1142

Petrungaro C, Zimmermann KM, Küttner V, Fischer M, Dengjel J, Bogeski I, Riemer J. (2015) The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake Cell Metab. 2015 doi: 10.1016/j.cmet.2015.08.019

Vavai SB & Mootha VK (2010) Mitochondrial disorders as windows into an ancient organelle. Nature 491: 374-483.