Chad Mirkin: Programmable Atom Equivalents and the Nature of the DNA Bond

Invited talk at Glasgow University - School of Chemistry 

Hosted by Ross Forgan

13.4.2016

Chad Mirkin

Northwestern University, Evanston, Wisconsin, USA

Talk abstract: http://www.chem.gla.ac.uk/school/events/abstract.php?LectureID=688

Mirkin group page: http://mirkin-group.northwestern.edu/

Chad Mirkin was awarded the Royal Society of Chemistry Centenary Prize in 2015  part of which is the Joseph Black Research Lecture at the School of Chemistry at Glasgow University.

Papers mentioned in the talk:

• Mirkin, C. A.; Letsinger, R. L.; Mucic, R. C.; Storhoff, J. J. “A DNA-Based Method for Rationally Assembling Nanoparticles into Macroscopic Materials,” Nature, 1996, 382, 607-609.
• Cutler, JI, Auyeung, E and Chad A. Mirkin C.A. Spherical Nucleic Acids  J. Am. Chem. Soc., 2012, 134 (3), pp 1376–1391 DOI:10.1021/ja209351u
• Rosi, N. L.; Mirkin, C. A. “Nanostructures in biodiagnostics,” Chemical Reviews, 2005,105, 1547-1562.
• Cutler, J. I.; Auyeung, E; Mirkin, C. A.  “Spherical Nucleic Acids”  J. Am. Chem. Soc., 2012, 134, 1376-1391. Doi 10.1021/ja209351u
• Radovic-Moreno, A.F. et al. "Immunomodulatory spherical nucleic acids" PNAS 112: (13) 3892-7.  doi: 10.1073/pnas.1502850112
• Rosi, N. L.; Giljohann, D. A.; Thaxton, C. S.; Lytton-Jean, A.; Han, M. S.; Mirkin, C. A. “Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation,” Science, 2006, 312, 1027-1030. Doi 10.1126/science.1125559
• Auyeung, E. et al. DNA-mediated nanoparticle crystallization into Wulff polyhedra. Nature 505, 73–77 doi:10.1038/nature12739
• Auyeung E. et al. Synthetically programmable nanoparticle superlattices using a hollow three-dimensional spacer approach. Nature Nanotechnology 7, 24–28 (2012) doi:10.1038/nnano.2011.222
• Auyeung, E.; Li, T.I.N.G; Senesi, A.J.; Schmucker, A.L.; Pals, B.C.; Olvera de la Cruz, M.; Mirkin, C.A. “DNA-mediated nanoparticle crystallization into Wulff polyhedra,” Nature, 2014, 505, 73-77, Doi 10.1038/nature12739
• Macfarlane, R. J.; Jones, M. R.; Lee, B.; Auyeung, E.; Mirkin, C. A. “Topotactic Interconversion of Nanoparticle Superlattices,” Science, 2013, 341, 1222-1225, Doi 10.1126/science.1241402
• Choi, C. H. J.; Hao, L.; Narayan, S. P.; Auyeung, E.; Mirkin, C. A. “Mechanism for the Endocytosis of Spherical Nucleic Acid Nanoparticle Conjugates,” Proc. Natl. Aca. Sci., 2013, 110, 7625-7630, Doi 10.1073/pnas.1305804110
• Zhang, C.; Macfarlane, R. J.; Young, K. L.; Choi, C. H. J.; Hao, L.; Auyeung, E.; Liu, G.; Zhou, X.; Mirkin, C. A. “A General Approach to DNA-Programmable Atom Equivalents,” Nature Materials, 2013, 12, 741-746, Doi 10.1038/nmat3647
• Auyeung, E.; Macfarlane, R. J.; Choi, C. H. J.; Cutler, J. I.; Mirkin, C. A. “Transitioning DNA-Engineered Nanoparticle Superlattices from Solution to the Solid State,” Adv. Mater.2012, 24, 5181-5186, Doi 10.1002/adma.201202069
• Jones MR, Seeman, NC, Mirkin CA Programmable materials and the nature of the DNA bond Science 347 (6224), DOI: 10.1126/science.1260901 REVIEW.

Pauling's rules: JACS; https://en.wikipedia.org/wiki/Pauling%27s_rules

Video of a recent talk by Chad Mirkin: https://www.youtube.com/watch?v=lV3Yhi9ib3Y